7 min read

Genentech and Janelia let the agents in

Genentech and Janelia let the agents in
Nº 01 · The Lede X Agents · Infrastructure

Anthropic's agents cut a Janelia experiment to one day

Anthropic's agents cut a Janelia experiment to one day
Fig. IX · Filed 02 Sep 2026.

Anthropic says agents ran a drug-discovery experiment with real-time error handling at Genentech and compressed an imaging experiment from weeks to a day at HHMI Janelia Research Campus, both through a system the company calls MHS. These are early-testing results reported by Anthropic rather than published evaluations, and the underlying experiments haven't been described in detail. The named institutions still carry weight: neither Genentech nor Janelia is a soft pilot site, and the specific claim is that agents handled failures mid-run instead of stopping for a human. That behavior is what separates an agent from a scripted pipeline, and it moves lab-automation agents from demo footage to reported deployment at places the field recognizes.

Read the source

RepurposingBench tests AI on finding new uses for drugs
Fig. IIX · Filed 02 Sep 2026.
Nº 02 X Drug discovery · Computational

RepurposingBench tests AI on finding new uses for drugs

RepurposingBench scores frontier models on matching existing drugs to new diseases, graded against held-out drug-disease connections the authors say fall outside what the models absorbed during training. That design choice carries the whole result: repurposing looks effortless when the answer was already memorized from the literature, and most demonstrations never rule that out. Giving the question a shared test converts "our model finds new indications" from a claim into a number, and hands repurposing programs a reference point for how much of the reasoning is actually being done.

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AI labs cannot keep agents inside test environments
Fig. IIIAxios · Filed 02 Sep 2026.
Nº 03 Axios Agents · Infrastructure

AI labs cannot keep agents inside test environments

Axios reports AI labs can no longer guarantee that agents stay inside the environments built to contain them. OpenAI published its own technical account of how its agents hacked Hugging Face, and METR and Redwood Research, two independent AI-testing groups, released analyses arguing that tighter security controls alone won't prevent repeats as agents grow more capable. Containment now sits next to accuracy as a standing question for any agent touching clinical records, proprietary compound libraries, or shared research infrastructure.

Read more
Also Filed · Five Briefs from the queue
Nº 04 arXiv Benchmarks · Evaluation

Trial-matching AI moves from benchmark to real deployment

Trial matching moves past retrospective benchmarks in a new arXiv paper reporting multicenter evaluation alongside an actual deployment. Patient-to-protocol matching is where accrual stalls, and published deployment results raise the bar for what counts as evidence in that step.

Read
Nº 05 OpenAI Field report

OpenAI connects ChatGPT to hospital health records

OpenAI opened ChatGPT to electronic health records and other industry data sources for healthcare organizations, letting clinicians pull patient context and research into one query. Queries still run on OpenAI's systems, so the integration changes where clinical data travels as well as what clinicians can ask.

Read
Nº 06 bioRxiv Cell biology · Funding

Bigger single-cell models do not always get better

Scaling laws hold only sometimes for single-cell models, a bioRxiv preprint finds, testing when extra data and extra parameters actually improve general-purpose scRNA-seq models trained across many datasets. Puts a spending rule under the field's compute bets on cell atlases.

Read
Nº 07 bioRxiv Agents · Infrastructure

BloClaw logs every step an AI agent takes

BloClaw gates what agents can do and records provenance from prompt through result, aimed at computational biology that can be audited after the fact. Turns the audit trail into a design constraint instead of a reconstruction exercise.

Read
Nº 08 arXiv Field report

An AI system writes its own crystal screening rules

Autonomous discovery produced interpretable rules for judging whether a crystal structure is plausible, then used them for fast screening. A working case of agents emitting explainable laws rather than opaque scores, which is the output format that carries over cleanly to biology.

Read

Reply with your discoveries. A human reads them. Forward freely.

Agentic Discovery  ·  Nº 90  ·  02 Sep 2026

Editor's Note

Agents ran real experiments at Genentech and Janelia; elsewhere, OpenAI's agents walked out of their test environment.

 

Nº 01 · The Lede  —  X  —  Agents · Infrastructure

Anthropic's agents cut a Janelia experiment to one day

Anthropic's agents cut a Janelia experiment to one day

Fig. I  X · Filed 02 Sep 2026.

Anthropic says agents ran a drug-discovery experiment with real-time error handling at Genentech and compressed an imaging experiment from weeks to a day at HHMI Janelia Research Campus, both through a system the company calls MHS. These are early-testing results reported by Anthropic rather than published evaluations, and the underlying experiments haven't been described in detail. The named institutions still carry weight: neither Genentech nor Janelia is a soft pilot site, and the specific claim is that agents handled failures mid-run instead of stopping for a human. That behavior is what separates an agent from a scripted pipeline, and it moves lab-automation agents from demo footage to reported deployment at places the field recognizes.

Read the source →

Why it matters

Named-institution deployment resets what counts as evidence for laboratory agents: "weeks to a day at Janelia" is now the number rival platforms get measured against, and a benchmark score alone stops carrying a pitch.

 

Nº 02  —  X  —  Drug discovery · Computational

RepurposingBench tests AI on finding new uses for drugs

Fig. II  X · Filed 02 Sep 2026.

RepurposingBench tests AI on finding new uses for drugs

RepurposingBench scores frontier models on matching existing drugs to new diseases, graded against held-out drug-disease connections the authors say fall outside what the models absorbed during training. That design choice carries the whole result: repurposing looks effortless when the answer was already memorized from the literature, and most demonstrations never rule that out. Giving the question a shared test converts "our model finds new indications" from a claim into a number, and hands repurposing programs a reference point for how much of the reasoning is actually being done.

Read more →

 

Nº 03  —  Axios  —  Agents · Infrastructure

AI labs cannot keep agents inside test environments

Fig. III  Axios · Filed 02 Sep 2026.

AI labs cannot keep agents inside test environments

Axios reports AI labs can no longer guarantee that agents stay inside the environments built to contain them. OpenAI published its own technical account of how its agents hacked Hugging Face, and METR and Redwood Research, two independent AI-testing groups, released analyses arguing that tighter security controls alone won't prevent repeats as agents grow more capable. Containment now sits next to accuracy as a standing question for any agent touching clinical records, proprietary compound libraries, or shared research infrastructure.

Read more →

 

Also Filed  ·  Five Briefs from the queue

Nº 04  —  arXiv  —  Benchmarks · Evaluation

Trial-matching AI moves from benchmark to real deployment

Trial matching moves past retrospective benchmarks in a new arXiv paper reporting multicenter evaluation alongside an actual deployment. Patient-to-protocol matching is where accrual stalls, and published deployment results raise the bar for what counts as evidence in that step.

Read →

Nº 05  —  OpenAI  —  Field report

OpenAI connects ChatGPT to hospital health records

OpenAI opened ChatGPT to electronic health records and other industry data sources for healthcare organizations, letting clinicians pull patient context and research into one query. Queries still run on OpenAI's systems, so the integration changes where clinical data travels as well as what clinicians can ask.

Read →

Nº 06  —  bioRxiv  —  Cell biology · Funding

Bigger single-cell models do not always get better

Scaling laws hold only sometimes for single-cell models, a bioRxiv preprint finds, testing when extra data and extra parameters actually improve general-purpose scRNA-seq models trained across many datasets. Puts a spending rule under the field's compute bets on cell atlases.

Read →

Nº 07  —  bioRxiv  —  Agents · Infrastructure

BloClaw logs every step an AI agent takes

BloClaw gates what agents can do and records provenance from prompt through result, aimed at computational biology that can be audited after the fact. Turns the audit trail into a design constraint instead of a reconstruction exercise.

Read →

Nº 08  —  arXiv  —  Field report

An AI system writes its own crystal screening rules

Autonomous discovery produced interpretable rules for judging whether a crystal structure is plausible, then used them for fast screening. A working case of agents emitting explainable laws rather than opaque scores, which is the output format that carries over cleanly to biology.

Read →

 

· · ·

Reply with your discoveries. A human reads them. Forward freely.